(2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

Base Information

Chemical Name:(2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid
CAS No.:1607826-15-2
Molecular Formula:C₃₃H₃₁NO₆
Molecular Weight:537.612
Hs Code.:

Synonyms:(2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

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Chemical Property of (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

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Technology Process of (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

There total 8 articles about (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1607826-49-2
methyl (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoate

: 1607826-15-2
(2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 - 14 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja502744a

Reference yield:

: 1607826-47-0
methyl (2R,3R)-2-azido-3-(4-(benzyloxy)phenyl)-3-methoxypropanoate

: 1607826-15-2
(2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / dichloromethane / 23 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 23 °C / Inert atmosphere

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 3 h / 0 - 14 °C / Inert atmosphere

With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja502744a

Reference yield:

: 1607826-46-9
methyl (2S,3R)-3-(4-(benzyloxy)phenyl)-3-hydroxy-2-(((2-nitrophenyl)sulfonyl)oxy)propanoate

: 1607826-15-2
(2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 23 - 50 °C / Inert atmosphere

2: silver(l) oxide / dichloromethane / 50 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / dichloromethane / 23 °C / Inert atmosphere

4: sodium hydrogencarbonate / water; tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 24 h / 23 °C / Inert atmosphere

6: lithium hydroxide monohydrate / water; tetrahydrofuran / 3 h / 0 - 14 °C / Inert atmosphere

With sodium azide; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; silver(l) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja502744a