O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

Base Information

• Chemical Name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
• CAS No.: 6723-30-4
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 29329990
• European Community (EC) Number: 628-109-4
• ChEMBL ID: CHEMBL1213808
• DSSTox Substance ID: DTXSID50408719
• Nikkaji Number: J1.564.419B
• Mol file: 6723-30-4.mol

Synonyms:6723-30-4;O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine;O-(Tetrahydropyran-2-yl)-hydroxylamine;O-(oxan-2-yl)hydroxylamine;2-(Aminooxy)tetrahydro-2H-pyran;O-(Tetrahydropyran-2-yl)hydroxylamine;O-(Tetrahydro-pyran-2-yl)-hydroxylamine;O-tetrahydropyran-2-ylhydroxylamine;MFCD01321374;O-Tertrahydroxy-Pyran-2-yl-Hydroxylamine;Hydroxylamine, O-(tetrahydro-2H-pyran-2-yl)-;O-(Tetrahydro-pyran-2-yl)hydroxylamine;H2NOTHP;NH2OTHP;tetrahydropyranyloxyamine;THPONH2;H2N-OTHP;2-tetrahydropyranyloxyamine;SCHEMBL42789;O-(TERTRAHYDROXY-PYRAN-2-YL)-HYDROXYLAMINE;O-tetrahydropyranylhydroxylamine;N-(2-tetrahydropyranyloxy)amine;CHEMBL1213808;O-tetrahydropyranyl hydroxylamine;Tetrahydropyranyl-O-Hydroxylamine;DTXSID50408719;o-(tetrahydropyranyl)hydroxylamine;tetrahydro-2H-pyran-2-yloxyamine;2-(aminooxy)tetrahydro-2H-pyrane;NLXXVSKHVGDQAT-UHFFFAOYSA-N;BCP33251;FD1322;O-(2-tetrahydropyranyl)-hydroxylamine;AKOS005146342;AC-4405;CS-W007325;GS-3273;O-(tetrahydro-2H-pyranyl)hydroxylamine;O-(Tetrahydropyran-2-yl)-Hydroxylamne;O-(tetrahydro-2H-pyran-yl)hydroxylamine;o-tetrahydro-2h-pyran-2-yl-hydroxyamine;O-tetrahydro-2H-pyran-2-ylhydroxylamine;O-tetrahydro-2H-pyran-2yl-hydroxylamine;O-(tetrahydro-pyran-2-yl)-hydroxyl-amine;O-tetrahydro-2H-pyran-2-yl-hydroxylamine;SY004632;O-(tetrahydro-2H-pyran-2-yl)-hydroxylamin;AM20100619;FT-0600197;O-(tetrahydro-2H-pyran-2-yl) hydroxylamine;O-(tetrahydro-2H-pyran-2-yl)-hydroxylamine;T2598;EN300-61519;N-(3-Chloropropyl)-N,O-dimethylhydroxylamine;O-(tetrahydro-2H-pyran-2-yl)- hydroxylamine;o-(tetrahydro-2h-pyran-2(rs)-yl)hydroxylamine;o-(tetrahydro-2h-pyran-2(rs)-yl)-hydroxylamine;A835675;O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine, 96%;J-523807;Z968560364;5,6-dimethyl-6-tetrahydropyran-2-yl-cyclohexa-1,3-dien-1-amine

Chemical Property of O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

Chemical Property:

• Vapor Pressure: 0.204mmHg at 25°C
• Melting Point: 34-37 °C(lit.)
• Refractive Index: 1.463
• Boiling Point: 209.322 °C at 760 mmHg
• PKA: 3.28±0.20(Predicted)
• Flash Point: 94.498 °C
• PSA: 44.48000
• Density: 1.069 g/cm³
• LogP: 1.10360
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

99% ^*data from raw suppliers

o-(Tetrahydro-2H-pyran-2-yl)hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)ON
• Uses: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine can be used to treat fibrotic and inflammatory diseases. O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as an oximation reagent in the synthesis of a marine alkaloid which shows significant inhibitory activity against mycothiol S-conjugate amidase.

Technology Process of O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

There total 2 articles about O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

→ O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + 2-[(tetrahydro-2H-pyran-2-yl)oxy]isoindoline-1,3-dione (6584-60-7)

Guidance literature:

Reference yield:

→ O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

Reference yield: 98.0%

O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + 4-((tetrabromo-2H-benzo[d][1,2,3]triazol-2-yl)methyl)benzoic acid → 4-((tetrabromo-2H-benzo[d][1,2,3]triazol-2-yl)methyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)benzamide

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.3390/molecules25071497

Downstream raw materials:

2-Hydroxy-3-phenyl-N-(tetrahydro-2H-2-pyranyloxy)propionamid

(Z)-4-<<(benzyloxy)carbonyl>amino>-α-<<(tetrahydro-2H-pyran-2-yl)oxy>imino>phenylacetic acid

3-Hydroxy-5-phenyl-N-(2-tetrahydropyranyloxy)thiophen-2-carboxamid

N-[(E)-3-(3-Phenoxy-phenyl)-allyl]-O-(tetrahydro-pyran-2-yl)-hydroxylamine