4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide

Base Information

• Chemical Name: 4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide
• CAS No.: 952734-85-9
• Molecular Formula: C₁₆H₁₉ClN₂O₃
• Molecular Weight: 322.791
• Mol file: 952734-85-9.mol

Synonyms:4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide

Chemical Property of 4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide

Chemical Property:

• Density: 1.28±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide

There total 1 articles about 4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Aminopiperidine (2213-43-6) + 4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester (169544-41-6) → 4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide (952734-85-9)

Guidance literature:

With triethylamine; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1007/s00706-008-0903-7

Reference yield:

4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide (952734-85-9) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → rimonabant (168273-06-1)

Guidance literature:

In ethanol; for 8h; Product distribution / selectivity;

Reference yield:

4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide (952734-85-9) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → rimonabant (168273-06-1) + N-(piperidin-1-yl)-3-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-5-carboxamide

Guidance literature:

In ethanol; at 25 ℃; for 8h; Inert atmosphere;

DOI:10.1007/s00706-008-0903-7

upstream raw materials:

1-Aminopiperidine

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester

Downstream raw materials:

rimonabant