N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

Base Information

Chemical Name:N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea
CAS No.:847606-81-9
Molecular Formula:C₁₆H₁₂ClF₃N₆O
Molecular Weight:396.759
Hs Code.:

Synonyms:N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

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Chemical Property of N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

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Technology Process of N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

There total 4 articles about N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 847606-83-1
1-(3-amino-benzyl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea

: 122-51-0
orthoformic acid triethyl ester

: 847606-81-9
N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

Guidance literature:: 1-(3-amino-benzyl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea; orthoformic acid triethyl ester; With sodium azide; acetic acid; at 20 - 75 ℃; for 1.16667h;

With hydrogenchloride; sodium nitrite; In water; at 20 ℃;

Reference yield:

: 847606-82-0
1-(4-chloro-3-trifluoromethyl-phenyl)-3-(3-nitro-benzyl)-urea

: 847606-81-9
N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 760.05 Torr

2.1: sodium azide; acetic acid / 1.17 h / 20 - 75 °C

2.2: 20 °C

With sodium azide; hydrogen; acetic acid; palladium 10% on activated carbon; In methanol;

Reference yield:

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 847606-81-9
N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{[3-(1H-tetrazol-1-yl)phenyl]methyl}urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 2 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium azide; acetic acid / 1.17 h / 20 - 75 °C

3.2: 20 °C

With sodium azide; hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;