(2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

Base Information

Chemical Name:(2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine
CAS No.:136591-52-1
Molecular Formula:C₃₄H₃₈N₄
Molecular Weight:502.703
Hs Code.:

Synonyms:(2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

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Chemical Property of (2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

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Technology Process of (2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

There total 5 articles about (2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 136573-95-0
4-Ethyl-1-<2-(1(H)-indol-3-yl)-ethyl>-3-(1,3-dimethyl-4,5-diphenylimidazolidin-2-yl)-1,4-dihydropyridine

: 136591-52-1
(2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1016/0040-4039(91)80605-6

Reference yield: 70.0%

: 3-{2-[3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-4-ethyl-4H-pyridin-1-yl]-ethyl}-1H-indole

: 136591-52-1
(2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

Guidance literature:: With hydrogenchloride; In methanol; for 12h; Ambient temperature;
DOI:10.1021/jo00086a045

Reference yield:

: 50720-05-3
indolyl acetyl chloride

: 136591-52-1
(2R,12bS)-3-((4S,5S)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-2-ethyl-1,2,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / LiBr / tetrahydrofuran

2: LiAlH₄ / diethyl ether / 12 h / Heating

3: 75 percent / HCl / methanol

With hydrogenchloride; lithium aluminium tetrahydride; lithium bromide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/0040-4039(91)80605-6