Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Base Information

Chemical Name:Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate
CAS No.:280779-86-4
Molecular Formula:C₁₈H₁₅F₂NO₇S
Molecular Weight:427.382
Hs Code.:

Synonyms:Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

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Chemical Property of Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

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Technology Process of Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

There total 3 articles about Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 76903-88-3
3,4-difluorobenzoyl chloride

: 107124-28-7
dimethyl 2,2-dioxo-5-methyl-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate

: 280779-86-4
Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Guidance literature:: dimethyl 2,2-dioxo-5-methyl-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate; With lithium hexamethyldisilazane;

3,4-difluorobenzoyl chloride;
DOI:10.1039/b001521k

Reference yield:

: 75475-91-1
dimethyl 5-methyl-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate

: 280779-86-4
Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / MCPBA / CH₂Cl₂ / 4 h / 0 - 20 °C

2.1: LiHMDS / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 51 percent / tetrahydrofuran; hexane / -78 - 20 °C

With 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b103250j

Reference yield:

: C₆H₇NO₂S

: 280779-86-4
Dimethyl 1-(3,4-difluorobenzoyl)-2,2-dioxo-5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

2: MCPBA

3: 51 percent / LHMDS

With 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; 1: Addition / 2: Oxidation / 3: Metallation / 3: Acylation;
DOI:10.1039/b001521k