acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

Base Information

Chemical Name:acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)
CAS No.:107699-74-1
Molecular Formula:C₁₂H₁₂F₃N₅O₂
Molecular Weight:315.255
Hs Code.:

Synonyms:acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

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Technology Process of acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

There total 4 articles about acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 107699-72-9
3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoate d'ethyle (3-R,S)

: 107699-74-1
acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 1.5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90554-X

Reference yield:

: 31694-91-4
5-amino 2-phenylmethyl 2-H-tetrazole

: 107699-74-1
acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / benzene / 5 h / 50 °C

2: methanol; CH₂Cl₂ / 3 h / Ambient temperature

3: 1.) Zn / 1.) methylal, ultrason, reflux then 1 h rt, 2.) reflux, 21 h

4: 94 percent / 2N aq. NaOH / dioxane / 1.5 h / Ambient temperature

With sodium hydroxide; zinc; In 1,4-dioxane; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)90554-X

Reference yield:

: 107699-70-7
1-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>2,2,2-trifluoroethanol (1-R,S)

: 107699-74-1
acide 3-<<2-(phenylmethyl)-2H-tetrazol-5-yl>amino>-4,4,4-trifluoro-butanoique (3-R,S)

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) Zn / 1.) methylal, ultrason, reflux then 1 h rt, 2.) reflux, 21 h

3: 94 percent / 2N aq. NaOH / dioxane / 1.5 h / Ambient temperature

With sodium hydroxide; zinc; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)90554-X