2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione
CAS No.:1464832-61-8
Molecular Formula:C₂₅H₁₈ClN₃O₂S
Molecular Weight:459.956
Hs Code.:

Synonyms:2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

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Chemical Property of 2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

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Technology Process of 2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

There total 8 articles about 2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1464832-59-4
(S)-2-(1-(3,5-dichloroquinoxalin-2-yl)ethyl)isoindoline-1,3-dione

: 168618-42-6
(2-methylsulfanylphenyl)boronic acid

: 1464832-61-8
2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1464832-53-8
8-chloro-3-ethyl-3,4-dihydroquinoxalin-2(1H)-one

: 1464832-61-8
2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 3 h / 45 °C / Large scale

2: trichlorophosphate / 2 h / 100 °C / Large scale

3: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux; Large scale

4: N,N-dimethyl-formamide / 3 h

5: CHIRALPAK? AS 20 μM, 11 cm id×25 cm L / hexane; isopropyl alcohol / 25 °C / Resolution of racemate

6: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; hexane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 64182-61-2
1-chloro-3-fluoro-2-nitrobenzene

: 1464832-61-8
2-((1S)-1-(5-chloro-3-(2-(methylthio)phenyl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 80 - 110 °C / Large scale

2: tin(II) chloride dihdyrate; hydrogenchloride / water; ethanol / 5 h / Reflux; Large scale

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 3 h / 45 °C / Large scale

4: trichlorophosphate / 2 h / 100 °C / Large scale

5: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux; Large scale

6: N,N-dimethyl-formamide / 3 h

7: CHIRALPAK? AS 20 μM, 11 cm id×25 cm L / hexane; isopropyl alcohol / 25 °C / Resolution of racemate

8: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tin(II) chloride dihdyrate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; ethanol; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;