7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride

Base Information

• Chemical Name: 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride
• CAS No.: 1254041-29-6
• Molecular Formula: C₁₉H₂₃ClN₆O₂*ClH
• Molecular Weight: 439.345
• Mol file: 1254041-29-6.mol

Synonyms:7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride

Chemical Property of 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride

There total 4 articles about 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

theophylline (58-55-9,75448-53-2) + 1-(2-chlorophenyl)-4-(2-chloroethyl)-piperazine (63377-89-9) → 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride (1254041-29-6)

Guidance literature:

theophylline; 1-(2-chlorophenyl)-4-(2-chloroethyl)-piperazine; With toluene-4-sulfonic acid; In acetonitrile; at 80 - 82 ℃; for 20h;

With hydrogenchloride; In isopropyl alcohol; pH=2 - 2.5;

Reference yield:

KMUP-1 (81996-46-5) → 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride (1254041-29-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 50 - 60 ℃; pH=1.2; Product distribution / selectivity; Saturated solution;

Reference yield:

N-(o-Chlorophenyl)piperazine (39512-50-0) → 7-[2-[4-(2-chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine hydrogen chloride (1254041-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 3 h / Reflux

2: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; sodium hydroxide; In ethanol; water;

upstream raw materials:

KMUP-1

N-(o-Chlorophenyl)piperazine

theophylline

1-(2-chlorophenyl)-4-(2-chloroethyl)-piperazine