methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

Base Information

Chemical Name:methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate
CAS No.:954410-31-2
Molecular Formula:C₃₈H₃₇N₃O₅
Molecular Weight:615.729
Hs Code.:

Synonyms:methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

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Chemical Property of methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

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Technology Process of methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

There total 8 articles about methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 954382-62-8
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazole-4-carboxylic acid

: 954410-30-1
methyl 3-[4-(2-naphthyl)piperidin-4-yl]propanoate

: 954410-31-2
methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 37859-25-9
2-naphthylacetyl chloride

: 954410-31-2
methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 2.5 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 1.5 h / 70 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

5.2: 3 h / 0 - 20 °C

6.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 2 h / 1551.49 Torr

7.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With n-butyllithium; 1-hydroxy-7-aza-benzotriazole; borane-THF; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 954409-71-3
1-[(benzyloxy)carbonyl]-4-(2-naphthyl)piperidine-4-carboxylic acid

: 954410-31-2
methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 2 h / 1551.49 Torr

4.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With n-butyllithium; 1-hydroxy-7-aza-benzotriazole; borane-THF; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; hexane; dichloromethane;