Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS No.: 89889-75-8
• Molecular Formula: C₂₄H₂₆N₄O₈
• Molecular Weight: 498.492

Synonyms:Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property of Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 2 articles about Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Benzyl-3-methyl-1-trimethylsilanyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (89908-13-4) + 1,2,3,5-tetraacetylribose (13035-61-5) → Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (89889-75-8)

Guidance literature:

With tin(IV) chloride; In acetonitrile; at 25 ℃; for 18h; Yield given;

DOI:10.1021/jm00374a009

Reference yield:

6-Benzyl-3-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (80030-90-6) → Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (89889-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (NH₄)2SO₄ / 8 h / Heating

2: SnCl₄ / acetonitrile / 18 h / 25 °C

With ammonium sulfate; tin(IV) chloride; In acetonitrile;

DOI:10.1021/jm00374a009

Reference yield: 78.0%

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-benzyl-3-methyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (89889-75-8) → 6-Benzyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (89889-83-8)

Guidance literature:

With ammonia; at 0 ℃; for 18h;

DOI:10.1021/jm00374a009

upstream raw materials:

6-Benzyl-3-methyl-1-trimethylsilanyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one

1,2,3,5-tetraacetylribose

6-Benzyl-3-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one

Downstream raw materials:

6-Benzyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one

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