ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
CAS No.:1092953-06-4
Molecular Formula:C₁₇H₁₄BrCl₂N₃O₂S
Molecular Weight:475.193
Hs Code.:

Synonyms:ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

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Chemical Property of ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

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Technology Process of ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

There total 3 articles about ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₅Cl₂N₃O₂S

: 1092953-06-4
ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: With N-Bromosuccinimide; In tetrachloromethane; at 70 ℃;
DOI:10.1021/acs.jmedchem.7b01914

Reference yield:

: C₂₁H₂₁Cl₂N₃O₄S

: 1092953-06-4
ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium / 1.5 h / 43 - 78 °C / Inert atmosphere

2: N-Bromosuccinimide / tetrachloromethane / 70 °C

With N-Bromosuccinimide; lithium; In tetrachloromethane;
DOI:10.1021/acs.jmedchem.7b01914

Reference yield:

: (S)-α-3-oxobutanoyloxypropionic isopropyl ester

: 1092953-06-4
ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / propan-1-ol / 16 h / 80 °C

2: lithium / 1.5 h / 43 - 78 °C / Inert atmosphere

3: N-Bromosuccinimide / tetrachloromethane / 70 °C

With N-Bromosuccinimide; sodium acetate; lithium; In propan-1-ol; tetrachloromethane;
DOI:10.1021/acs.jmedchem.7b01914