2,2-diethyl-N¹,N³-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide

Base Information

• Chemical Name: 2,2-diethyl-N¹,N³-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide
• CAS No.: 934558-93-7
• Molecular Formula: C₂₅H₃₄N₂O₆
• Molecular Weight: 458.555

Synonyms:2,2-diethyl-N¹,N³-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide

Chemical Property of 2,2-diethyl-N¹,N³-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide

Chemical Property:

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Technology Process of 2,2-diethyl-N¹,N³-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide

There total 1 articles about 2,2-diethyl-N¹,N³-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N1,N3-di{(1S)-1-[4-(benzyloxy)benzyl]-2-hydroxyethyl}-2,2-diethylmanonamide (600738-28-1) → 2,2-diethyl-N1,N3-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide (934558-93-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 18h; under 3750.38 Torr;

DOI:10.1002/ejoc.200600827

Reference yield: 86.0%

2,2-diethyl-N1,N3-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide (934558-93-7) → N1,N3-bis[(S)-1-(chloromethyl)-2-(4-hydroxyphenyl)ethyl]-2,2-diethylmalonamide

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1002/ejoc.200600827

Reference yield: 59.0%

2,2-diethyl-N1,N3-bis[(S)-1-(hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]malonamide (934558-93-7) + 1,5-dibromo-pentane (111-24-0) → N1,N3-bis{(S)-2-[4-(5-bromopentyloxy)phenyl]-1-(hydroxymethyl)ethyl}-2,2-diethylmalonamide (934558-99-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 18h; Heating;

DOI:10.1002/ejoc.200600827

upstream raw materials:

N₁,N₃-di{(1S)-1-[4-(benzyloxy)benzyl]-2-hydroxyethyl}-2,2-diethylmanonamide

Downstream raw materials:

N¹,N³-bis{(S)-2-[4-(2-bromoetoxy)phenyl]-1-(hydroxymethyl)ethyl}-2,2-diethylmalonamide

N¹,N³-bis{(S)-2-[4-(3-bromopropoxy)phenyl]-1-(hydroxymethyl)ethyl}-2,2-diethylmalonamide

N¹,N³-bis{(S)-2-[4-(4-bromobutoxy)phenyl]-1-(hydroxymethyl)ethyl}-2,2-diethylmalonamide

N¹,N³-bis{(S)-2-[4-(5-bromopentyloxy)phenyl]-1-(hydroxymethyl)ethyl}-2,2-diethylmalonamide

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