(S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

Base Information

Chemical Name:(S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate
CAS No.:108168-28-1
Molecular Formula:C₂₀H₂₁F₃O₆
Molecular Weight:414.378
Hs Code.:

Synonyms:(S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

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Chemical Property of (S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

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Technology Process of (S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

There total 4 articles about (S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108266-34-8
(S)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7,7-(ethylenedioxy)bicyclo<3.3.0>octane-2-carboxylate

: 108168-28-1
(S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1021/jo00387a026

Reference yield:

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 108168-28-1
(S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / CH₂Cl₂ / 16 h / Ambient temperature

2: 95 percent / 2N HCl / tetrahydrofuran / 16 h / Ambient temperature

With pyridine; hydrogenchloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00387a026

Reference yield:

: 69552-47-2,71773-24-5,82863-52-3,89888-63-1,122292-76-6,130549-62-1,130549-63-2
methyl (+/-)-3-oxo-7,7-(ethylenedioxy)bicyclo<3.3.0>octane-2-carboxylate

: 108168-28-1
(S)-(-)-α-methoxy-α-(trifluoromethyl)pnenylacetyl acid ester of methyl (+)-(1R,2R,3S,5S)-3-hydroxy-7-oxobicyclo<3.3.0>octane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / H₂O / 48 h / 25 °C / pH₇ phosphate buffer, D-glucose, yeast extract, active bakers' yeast

2: 98 percent / pyridine / CH₂Cl₂ / 16 h / Ambient temperature

3: 95 percent / 2N HCl / tetrahydrofuran / 16 h / Ambient temperature

With pyridine; hydrogenchloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00387a026