2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

Base Information

Chemical Name:2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide
CAS No.:949115-24-6
Molecular Formula:C₁₇H₂₀INO₄
Molecular Weight:429.255
Hs Code.:

Synonyms:2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

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Chemical Property of 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

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Technology Process of 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

There total 1 articles about 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 33082-77-8
2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)ethanoic acid

: 153898-63-6
2-iodo-5-methoxyaniline

: 949115-24-6
2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 15h; Heating;
DOI:10.1021/ol0712576

Reference yield:

: 949115-24-6
2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

: (+/-)-9-methoxy-3-benzyl-2,5-dioxo-1,2,3,3a,4,5,6,6a-octahydro-7H-pyrrolo[2,3-d]carbazole-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / dppe; PMP / Pd₂(dba)3 / N,N-dimethyl-acetamide / 3 h / 110 °C

2: aq. HCl / H₂O; tetrahydrofuran / 20 °C

3: 5.67 g / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 20 °C

4: 64 percent / acetic acid; SeO₂ / 2-methyl-propan-2-ol / 72 h / 100 °C

5: 93 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

6: 73 percent / methanol; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; dmap; selenium(IV) oxide; 2-isovalerylindane-1,3-dione; acetic acid; triethylamine; 1,2-bis-(diphenylphosphino)ethane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; tert-butyl alcohol; 1: Heck reaction;
DOI:10.1021/ol0712576

Reference yield:

: 949115-24-6
2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2-iodo-5-methoxyphenyl)acetamide

: C₂₁H₂₀N₂O₂CH₂O

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / dppe; PMP / Pd₂(dba)3 / N,N-dimethyl-acetamide / 3 h / 110 °C

2: aq. HCl / H₂O; tetrahydrofuran / 20 °C

3: 5.67 g / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 20 °C

4: 64 percent / acetic acid; SeO₂ / 2-methyl-propan-2-ol / 72 h / 100 °C

5: 93 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

6: 73 percent / methanol; tetrahydrofuran / 4 h / 20 °C

7: trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

With hydrogenchloride; dmap; selenium(IV) oxide; 2-isovalerylindane-1,3-dione; acetic acid; triethylamine; trifluoroacetic acid; 1,2-bis-(diphenylphosphino)ethane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; tert-butyl alcohol; 1: Heck reaction;
DOI:10.1021/ol0712576