5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

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Chemical Name:5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol
CAS No.:1354042-34-4
Molecular Formula:C₁₇H₁₁F₂N₅O₂
Molecular Weight:355.303
Hs Code.:

Synonyms:5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

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Chemical Property of 5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

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Technology Process of 5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

There total 1 articles about 5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 37032-44-3
ethyl 3-(dimethylamino)-2-fluoroacrylate

: 1354044-31-7
1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazole-3-carboximidamide

: 1354042-34-4
5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

Guidance literature:: With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 110 ℃; for 16h;
DOI:10.1021/acsmedchemlett.5b00479

Reference yield:

: 1354042-34-4
5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

: C₂₁H₁₄F₈N₆O₂

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / 23 - 65 °C

2: triethylamine / 1,4-dioxane; water / 120 h / 23 - 100 °C

With triethylamine; trichlorophosphate; In 1,4-dioxane; water;

Reference yield:

: 1354042-34-4
5-fluoro-2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

: C₂₁H₁₆F₅N₇O₃

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / 23 - 65 °C

2: triethylamine / 1,4-dioxane; water / 48 h / 23 - 100 °C

With triethylamine; trichlorophosphate; In 1,4-dioxane; water;