2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

Base Information

Chemical Name:2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide
CAS No.:1021498-00-9
Molecular Formula:C₂₀H₂₀BrN₃O₂S
Molecular Weight:446.368
Hs Code.:

Synonyms:2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

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Chemical Property of 2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

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Technology Process of 2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

There total 5 articles about 2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.1%

: 1021497-75-5
4-[2-(4-bromo-phenylsulfanyl)-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester

: 1021498-00-9
2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1021498-05-4
methyl 4-nitro-1-(2-phenylethyl)-1H-pyrazole-3-carboxylate

: 1021498-00-9
2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 30402 Torr

2: triethylamine / tetrahydrofuran / 24 h

3: triethylamine / tetrahydrofuran / 1 h

4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 103-63-9
1-phenyl-2-bromoethane

: 1021498-00-9
2-(4-bromo-phenylsulfanyl)-N-(3-hydroxymethyl-1-phenethyl-1H-pyrazol-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 24 h

2: hydrogen / palladium 10% on activated carbon / methanol / 0.5 h / 30402 Torr

3: triethylamine / tetrahydrofuran / 24 h

4: triethylamine / tetrahydrofuran / 1 h

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen; caesium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;