2,4-Dichloro-6-iodoaniline

Base Information

• Chemical Name: 2,4-Dichloro-6-iodoaniline
• CAS No.: 697-90-5
• Molecular Formula: C6H4Cl2IN
• Molecular Weight: 287.915
• Hs Code.: 2921420090
• DSSTox Substance ID: DTXSID40428820
• Nikkaji Number: J1.909.836B
• Wikidata: Q72466533
• Mol file: 697-90-5.mol

Synonyms:2,4-dichloro-6-iodoaniline;697-90-5;SCHEMBL2766389;DTXSID40428820;2,4-Dichloro-6-iodo-phenylamine;YJRSMJTVXWBFJJ-UHFFFAOYSA-N;Benzenamine, 2,4-dichloro-6-iodo-;MFCD08533279;AKOS016008826;AM61652;CS-W010011;SB82449;AS-33282;FT-0610023;A856473;AS-813/43502131

Chemical Property of 2,4-Dichloro-6-iodoaniline

Chemical Property:

• Vapor Pressure: 0.000911mmHg at 25°C
• Melting Point: 59-62 °C(lit.)
• Refractive Index: 1.699
• Boiling Point: 303.8 °C at 760 mmHg
• Flash Point: 137.5 °C
• PSA: 26.02000
• Density: 2.091 g/cm³
• LogP: 3.76140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 286.87655
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloro-6-iodoaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Hazard Codes: T,N
• Statements: 23/24/25-33-50/53
• Safety Statements: 28-36/37-45-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1Cl)N)I)Cl

Technology Process of 2,4-Dichloro-6-iodoaniline

There total 1 articles about 2,4-Dichloro-6-iodoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dichloroaniline (554-00-7,51908-09-9) → 2,4-dichloro-6-iodoaniline (697-90-5)

Guidance literature:

With Iodine monochloride; acetic acid;

Reference yield: 98.0%

2,4-dichloro-6-iodoaniline (697-90-5) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(2-amino-3,5-dichlorophenyl)acrylate

Guidance literature:

With palladium 10% on activated carbon; triethylamine; In 1,4-dioxane; at 100 ℃; for 20h; Schlenk technique;

DOI:10.1055/s-0036-1590895

Reference yield: 95.0%

2,4-dichloro-6-iodoaniline (697-90-5) + 3-(2-methoxybenzylidene)dihydrofuran-2-one (505904-79-0) → N-(2,4-dichloro-6-iodophenyl)-2-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide (535932-37-7)

Guidance literature:

2,4-dichloro-6-iodoaniline; With trimethylaluminum; In hexane; benzene; at 0 - 20 ℃; for 0.75h;

3-(2-methoxybenzylidene)dihydrofuran-2-one; In hexane; benzene; for 15h; Heating;

DOI:10.1021/ol034314d

upstream raw materials:

2,4-Dichloroaniline

Downstream raw materials:

3,5-dichloroiodobenzene

N-(2,4-dichloro-6-iodophenyl)-2-(2-hydroxyethyl)-3-(4-bromophenyl)acrylamide

N-(2,4-dichloro-6-iodophenyl)-2-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide

5,7-dichloro-2-phenyl-1H-indole

Refernces

• 1、 Fernandes, Manuel A.,Reid, David H.. "Synthesis of 3,1-Benzothiazines by Cyclisation of 2- Thioformylaminodiphenylacetylenes". . p. 2231 - 2233. Retrieved 2007/10/03.