[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester
CAS No.:147961-05-5
Molecular Formula:C₃₄H₃₁ClN₂O₃S
Molecular Weight:583.151
Hs Code.:

Synonyms:[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

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Chemical Property of [1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

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Technology Process of [1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

There total 10 articles about [1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 147961-05-5
[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 1.5 h / 0 °C

2: AcONa, AcOH / toluene / 1.5 h / 70 °C

3: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

4: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

With sodium acetate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: 66762-71-8
4-tert-butylsulfanyl-3-oxo-butyric acid ethyl ester

: 147961-05-5
[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: AcONa, AcOH / toluene / 1.5 h / 70 °C

2: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

3: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

With sodium acetate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: [5-Allyloxy-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-1H-indol-2-yl]-acetic acid ethyl ester

: 147961-05-5
[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

With caesium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00034a013