2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

Base Information

Chemical Name:2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene
CAS No.:154148-88-6
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

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Chemical Property of 2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

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Technology Process of 2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

There total 5 articles about 2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 917-54-4
methyllithium

: 154148-87-5
2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-oxo-1'-(5''-imidazolyl)methyl)toluene

: 154148-88-6
2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

Guidance literature:: In tetrahydrofuran; 1.) -78 deg. C, 1 h, 2.) -78 - 0 deg.C, 1 h;
DOI:10.1002/jhet.5570300631

Reference yield:

: 83647-43-2
3-bromo-2-methylbenzyl alcohol

: 154148-88-6
2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 1.) NaH / dimethylformamide / 1.) 0 deg.C, 30 min, 2.) 30 deg.C, 3 h

2: 1.) Mg / 1.) THF, reflux, 2.5 h, 2.) THF, reflux 3 h

3: 82 percent / pyridinium chlorochromate / CH₂Cl₂ / 36 h / 25 °C

4: 90 percent / tetrahydrofuran / 1.) -78 deg. C, 1 h, 2.) -78 - 0 deg.C, 1 h

With sodium hydride; magnesium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570300631

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 154148-88-6
2-(((3',4'dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'methyl-1'-(5''-imidazolyl)methyl)toluene

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AlCl₃, Br₂, 2.) NaBH₄ / 1.) CH₂Cl₂, 40 deg.C, 30 min, 2.) CH₃OH, 0 deg.C, 2 h

2: 75 percent / 1.) NaH / dimethylformamide / 1.) 0 deg.C, 30 min, 2.) 30 deg.C, 3 h

3: 1.) Mg / 1.) THF, reflux, 2.5 h, 2.) THF, reflux 3 h

4: 82 percent / pyridinium chlorochromate / CH₂Cl₂ / 36 h / 25 °C

5: 90 percent / tetrahydrofuran / 1.) -78 deg. C, 1 h, 2.) -78 - 0 deg.C, 1 h

With sodium tetrahydroborate; aluminium trichloride; bromine; sodium hydride; magnesium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570300631