N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

Base Information

Chemical Name:N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea
CAS No.:1380067-75-3
Molecular Formula:C₂₁H₂₃FN₄O₃
Molecular Weight:398.437
Hs Code.:

Synonyms:N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

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Chemical Property of N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

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Technology Process of N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

There total 7 articles about N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-02-1
trimethylsilyl isocyanate

: 1380070-08-5
tert-butyl [(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]carbamate

: 1380067-75-3
N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

Guidance literature:: tert-butyl [(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]carbamate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

trimethylsilyl isocyanate; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 121219-03-2
4-bromo-3-fluorophenol

: 1380067-75-3
N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene; tetrahydrofuran / 3.5 h / 0 - 20 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C

4.1: perchloric acid; ethyl O-(2-mesitylenesulfonyl)acetohydroxamate / N,N-dimethyl-formamide; tetrahydrofuran / 0.83 h / 0 - 20 °C

4.2: 20 °C

5.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

5.2: 20 °C

With hydrogenchloride; perchloric acid; di-isopropyl azodicarboxylate; ethyl O-(2-mesitylenesulfonyl)acetohydroxamate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 55717-45-8,55717-40-3
6-bromo-pyridin-3-ol

: 1380067-75-3
N-[(1S)-2-{4-[6-(cyclopropylmethoxy)pyrazolo[1,5-a]pyridin-2-yl]-3-fluorophenoxy}-1-methylethyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C

3.1: perchloric acid; ethyl O-(2-mesitylenesulfonyl)acetohydroxamate / N,N-dimethyl-formamide; tetrahydrofuran / 0.83 h / 0 - 20 °C

3.2: 20 °C

4.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4.2: 20 °C

With hydrogenchloride; perchloric acid; ethyl O-(2-mesitylenesulfonyl)acetohydroxamate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;