N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide

Base Information

• Chemical Name: N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide
• CAS No.: 448944-47-6
• Molecular Formula: C₄₃H₅₉N₁₃O₇
• Molecular Weight: 870.024
• Mol file: 448944-47-6.mol

Synonyms:Ac-Nle-Ala-His-D-Phe-Arg-Trp-NH₂

Chemical Property of N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide

Chemical Property:

• PKA: 13.36±0.46(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Acetyl hexapeptide-1 is a synthetic peptide composed of the amino acids alanine, arginine, histidine, leucine, phenylalanine and tryptophan. It helps skin better defend itself from environmental aggressors by virtue of a calming effect. This peptide can also help promote a visibly more even skin tone by playing a role in how melanin moves through skin.Acetyl Hexapeptide-1 is a bit of a special snowflake among peptides as it's not a wrinkle-smoothing, anti-aging active like most of the other ones but it can stimulate pigmentation and melanin production (by interacting with a skin cell receptor called MC1R).As melanin not only gives the skin its nice tanned color but also works as a natural protection factor, Acetyl Hexapeptide-1, aka Melitane does the same. It not only boosts a natural or an artificial tan but gives extra protection against UV-induced DNA and free radical damage and protects the skin against UV-caused redness.

Technology Process of N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide

There total 1 articles about N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Acetyl-L-2-aminohexanoic acid (15891-49-3) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-Arg(Pbf)-OH (119831-72-0,157774-30-6) + Fmoc-D-Phe-OH (86123-10-6) + Fmoc-His(Trt)-OH (109425-51-6) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) → Ac-Nle-Ala-His-D-Phe-Arg-Trp-NH2 (448944-47-6)

Guidance literature:

N-Acetyl-L-2-aminohexanoic acid; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Arg(Pbf)-OH; Fmoc-D-Phe-OH; Fmoc-His(Trt)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; In DMF (N,N-dimethyl-formamide);

With piperidine; In DMF (N,N-dimethyl-formamide); ethylene glycol;

upstream raw materials:

N-Acetyl-L-2-aminohexanoic acid

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-Arg(Pbf)-OH

Fmoc-D-Phe-OH