2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine

Base Information

• Chemical Name: 2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine
• CAS No.: 168430-11-3
• Molecular Formula: C₁₀H₈N₄O₃
• Molecular Weight: 232.199
• Mol file: 168430-11-3.mol

Synonyms:2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine

Chemical Property of 2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine

There total 1 articles about 2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

ethyl 4-nitrobenzoylacetate (838-57-3) + diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) → 2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine (168430-11-3)

Guidance literature:

In ethanol; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2015.04.084

Reference yield: 100.0%

octadecyl isocyanate (112-96-9) + 2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine (168430-11-3) → 1-[6-(4-Nitro-phenyl)-4-oxo-1,4-dihydro-pyrimidin-2-yl]-3-octadecyl-urea

Guidance literature:

With pyridine; for 4h; Heating;

DOI:10.1021/ja974112a

Reference yield:

2-amino-1,6-dihydro-4-(4'-nitrophenyl)-6-oxopyrimidine (168430-11-3) → 2-(3-{4-[2-amino-6-(indan-2-ylamino)-pyrimidin-4-yl]-phenylamino}-propyl)-phenol

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃ / 3 h / 125 - 130 °C

2: Et₃N / butan-1-ol / 15 h / 120 °C

3: H₂ / 5 percent Pd/BaSO₄ / ethanol; tetrahydrofuran / 2.5 h / 20 °C

4: 59 percent / NaCNBH₃ / ethanol; acetic acid / 0.83 h

With hydrogen; sodium cyanoborohydride; triethylamine; trichlorophosphate; Pd-BaSO₄; In tetrahydrofuran; ethanol; acetic acid; butan-1-ol; 1: Chlorination / 2: Substitution / 3: Catalytic hydrogenation / 4: Substitution;

DOI:10.1021/jm990293a

upstream raw materials:

ethyl 4-nitrobenzoylacetate

diguanidine carbonate

Downstream raw materials:

4-chloro-6-(4-nitro-phenyl)-pyrimidin-2-ylamine

6-(4-amino-phenyl)-N⁴-indan-2-yl-pyrimidine-2,4-diamine