ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate
• CAS No.: 895582-15-7
• Molecular Formula: C₁₉H₁₈BrN₃O₂S
• Molecular Weight: 432.341
• Mol file: 895582-15-7.mol

Synonyms:ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate

Chemical Property of ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate

There total 2 articles about ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 6-[(1H-imidazol-2-yl)sulfanyl]pyridine-3-carboxylate (895582-14-6) + methanesulfonic acid 2-(2-bromophenyl)ethyl ester (2183-83-7) → ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate (895582-15-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Heating;

DOI:10.1016/j.tet.2006.02.071

Reference yield:

6-chloro-3-pyridinecarboxylic acid ethyl ester (49608-01-7) → ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate (895582-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / NaH / dimethylformamide / 12 h / 80 °C

2: 75 percent / NaH / dimethylformamide / Heating

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2006.02.071

Reference yield: 45.0%

ethyl 6-({1-[2-(2-bromophenyl)ethyl]-1H-imidazol-2-yl}sulfanyl)pyridine-3-carboxylate (895582-15-7) → 6-(1-phenethyl-1H-imidazol-2-ylsulfanyl)-nicotinic acid ethyl ester + 5,6-dihydroimidazo[2,1-a]isoquinoline (802875-94-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In toluene; Heating;

DOI:10.1016/j.tet.2006.02.071

upstream raw materials:

ethyl 6-[(1H-imidazol-2-yl)sulfanyl]pyridine-3-carboxylate

methanesulfonic acid 2-(2-bromophenyl)ethyl ester

6-chloro-3-pyridinecarboxylic acid ethyl ester

Downstream raw materials:

5,6-dihydroimidazo[2,1-a]isoquinoline