benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

Base Information

Chemical Name:benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate
CAS No.:1412257-27-2
Molecular Formula:C₁₉H₁₉ClF₃N₃O₃
Molecular Weight:429.826
Hs Code.:

Synonyms:benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

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Chemical Property of benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

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Technology Process of benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

There total 3 articles about benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

: 952443-94-6,1810070-09-7
benzyl (3R,4R)-4-hydroxypyrrolidin-3-ylcarbamate

: 1412254-65-9
(S)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl trifluoromethanesulfonate

: 1412257-27-2
benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 56 ℃; for 12h;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1412257-27-2
benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / 1,4-dioxane; water / 3 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: potassium carbonate / tetrahydrofuran / 12 h / 56 °C

With sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 952443-93-5
(3R,4R)-tert-butyl 3-(benzyloxycarbonylamino)-4-hydroxypyrrolidine-1-carboxylate

: 1412257-27-2
benzyl (3R,4R)-1-((R)-1-(6-chloropyridin-3-yl)-2,2,2-trifluoroethyl)-4-hydroxypyrrolidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: potassium carbonate / tetrahydrofuran / 12 h / 56 °C

With potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;