tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate

Base Information

• Chemical Name: tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate
• CAS No.: 1154424-63-1
• Molecular Formula: C₂₂H₂₆N₂O₄
• Molecular Weight: 382.459

Synonyms:tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate

Chemical Property of tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate

Chemical Property:

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MSDS Files:

SDS file from LookChem

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Technology Process of tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate

There total 2 articles about tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl alcohol (100-51-6,185532-71-2) + 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid (170097-67-3) → tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate (1154424-63-1)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; for 12h; Reflux; Inert atmosphere;

Reference yield:

tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (164148-92-9) + benzyl chloroformate (501-53-1,94274-21-2) → tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate (1154424-63-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield: 91.0%

tert-butyl 6-benzyloxycarbonylamino-3,4-dihydro-1H-isoquinoline-2-carboxylate (1154424-63-1) → tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (164148-92-9)

Guidance literature:

With ammonium formate; palladium(II) hydroxide; In ethanol; for 6h; Reflux;

upstream raw materials:

benzyl alcohol

2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

benzyl chloroformate

Downstream raw materials:

tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

benzyl (1,2,3,4-tetrahydro-isoquinolin-6-yl)-carbamate trifluoroacetate

C₂₀H₂₂N₆O₂S

3-(4-(2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ylamino)-5-methylpyrimidin-2-ylamino)benzenesulfonamide

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