4'-HYDROXY-2,2':6',2''-TERPYRIDINE

Base Information

• Chemical Name: 4'-HYDROXY-2,2':6',2''-TERPYRIDINE
• CAS No.: 101003-65-0
• Molecular Formula: C₁₅H₁₁N₃O
• Molecular Weight: 249.272
• Mol file: 101003-65-0.mol

Synonyms:2,6-Bis(2'-pyridyl)-4-hydroxypyridine;2,6-Bis(pyridine-2-yl)pyridine-4-ol;2,6-Di(2-pyridyl)-4-hydroxypyridine;

Chemical Property of 4'-HYDROXY-2,2':6',2''-TERPYRIDINE

Chemical Property:

• Melting Point: 178 °C
• Boiling Point: 505.5 °C at 760 mmHg
• PKA: 8.76±0.18(Predicted)
• Flash Point: 259.5 °C
• PSA: 58.90000
• Density: 1.269 g/cm³
• LogP: 2.91120

Purity/Quality:

99%, ^*data from raw suppliers

[2,2':6',2''-Terpyridin]-4'-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-HYDROXY-2,2':6',2''-TERPYRIDINE

There total 4 articles about 4'-HYDROXY-2,2':6',2''-TERPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,5-di-pyridin-3-yl-pentane-1,3,5-trione (1678-15-5) → 4'-hydroxy-2,2':6',2''-terpyridine (101003-65-0)

Guidance literature:

With ammonium acetate; for 6h; Reflux;

DOI:10.1039/c7nj03175k

Reference yield: 52.3%

2-acetylpyridine (1122-62-9) + carbonic acid dimethyl ester (616-38-6) → 4'-hydroxy-2,2':6',2''-terpyridine (101003-65-0)

Guidance literature:

2-acetylpyridine; carbonic acid dimethyl ester; With ethanol; sodium; at 35 ℃; for 24h; Inert atmosphere;

With ammonium hydroxide; at 20 - 40 ℃; for 26h; Inert atmosphere;

DOI:10.1002/aoc.6027

Reference yield:

ethyl-2-picolinate (2524-52-9,1228273-66-2) → 4'-hydroxy-2,2':6',2''-terpyridine (101003-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran

2: ammonium acetate

With ammonium acetate; sodium hydride; In tetrahydrofuran;

DOI:10.1007/s11696-017-0214-8

upstream raw materials:

ethyl-2-picolinate

1,5-bis(2′-pyridyl)pentane-1,3,5-trione

1,5-di-pyridin-3-yl-pentane-1,3,5-trione

2-acetylpyridine

Downstream raw materials:

4’-[phenylethynyl]-2,2’:6’,2’’-terpyridine

4'-Chloro-2,2':6',2''-terpyridine

Refernces

• 1、 He, Xuan,Zhang, Gao-Bin,Chi, Zi-Xin,Dai, Peng-Fei,Huang, Jian-Yan,Yang, Jia-Xiang. "Terpyridine functionalized α-cyanostilbene derivative as excellent fluorescence and naked eyes Fe2+ probe in aqueous environment". . p. 2209 - 2215. Retrieved 2017.
• 2、 Yang, Hewei,Wang, An,Zhang, Limin,Zhou, Xinyu,Yang, Guang,Li, Yanjie,Zhang, Yuzhe,Zhang, Bao,Song, Jian,Feng, Yaqing. "Healable terpyridine-based supramolecular gels and the luminescent properties of the rare earth metal complex". . p. 15173 - 15179. Retrieved 2017.