Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate

Base Information

Chemical Name:Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate
CAS No.:80022-73-7
Molecular Formula:C₁₃H₁₂BrNO₃
Molecular Weight:310.147
Hs Code.:
ChEMBL ID:CHEMBL5175086
DSSTox Substance ID:DTXSID801215448
Nikkaji Number:J2.955.978C

Synonyms:80022-73-7;CHEMBL5175086;Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate;DTXSID801215448;BDBM50598486;MFCD16657720;SY325782;Ethyl 2-(4-bromophenyl)-5-methyl-4-oxazolecarboxylate

Suppliers and Price of Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:309.00006
Heavy Atom Count:18
Complexity:292

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(OC(=N1)C2=CC=C(C=C2)Br)C

Technology Process of Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate

There total 1 articles about Ethyl 2-(4-Bromophenyl)-5-methyloxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 57332-84-0
3-bromo-2-oxo-butyric acid ethyl ester

: 698-67-9
p-bromobenzamide

: 80022-73-7
ethyl 2-(4-bromophenyl)-5-methyloxazole-4-carboxylate

Guidance literature:: With silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 90 ℃; for 3h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jo1025332

Reference yield: 60.0%

: 80022-73-7
ethyl 2-(4-bromophenyl)-5-methyloxazole-4-carboxylate

: 80022-52-2
ethyl 2-p-bromophenyl-5-bromomethyloxazole-4-carboxylate

Guidance literature:: With N-Bromosuccinimide; In tetrachloromethane; for 4h; Heating; Irradiation;

Reference yield:

: 80022-73-7
ethyl 2-(4-bromophenyl)-5-methyloxazole-4-carboxylate

: 80022-67-9
2-(4-Bromo-phenyl)-10H-1,9-dioxa-3-aza-benzo[f]azulen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / N-bromosuccinimide / CCl₄ / 4 h / Heating; Irradiation

2: 95 percent / butan-2-one / Heating; overnight

3: 90 percent / aq. NaOH / ethanol / 0.25 h / Heating

4: SOCl₂ / benzene / 5 h / Heating

5: SnCl₄ / CH₂Cl₂ / 1.) ambient temperature, overnight; 2.) reflux, 2 h

With sodium hydroxide; N-Bromosuccinimide; thionyl chloride; tin(IV) chloride; In tetrachloromethane; ethanol; dichloromethane; butanone; benzene;