Technology Process of 3-[(1s,4s)-4-(tert-butyl)cyclohexyl]propanoic acid
There total 3 articles about 3-[(1s,4s)-4-(tert-butyl)cyclohexyl]propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
allylmagnesium bromide;
With
copper(l) chloride;
In
diethyl ether;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
Toluolsulfonsaeure-(4)-;
In
diethyl ether;
at 0 - 20 ℃;
for 10h;
Inert atmosphere;
With
sodium periodate; ruthenium(III) chloride trihydrate;
In
tetrachloromethane; water; acetonitrile;
at 20 ℃;
for 9h;
DOI:10.1021/ja301685r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere
3.1: copper(l) chloride / diethyl ether / 0.33 h / 0 °C / Inert atmosphere
3.2: 10 h / 0 - 20 °C / Inert atmosphere
3.3: 9 h / 20 °C
With
dmap; lithium aluminium tetrahydride; triethylamine; copper(l) chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja301685r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere
2.1: copper(l) chloride / diethyl ether / 0.33 h / 0 °C / Inert atmosphere
2.2: 10 h / 0 - 20 °C / Inert atmosphere
2.3: 9 h / 20 °C
With
dmap; triethylamine; copper(l) chloride;
In
diethyl ether; dichloromethane;
DOI:10.1021/ja301685r
