(S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate

Base Information

• Chemical Name: (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate
• CAS No.: 1001912-82-8
• Molecular Formula: C₁₉H₂₄O₄S
• Molecular Weight: 348.463
• Mol file: 1001912-82-8.mol

Synonyms:(S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate

Chemical Property of (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate

There total 9 articles about (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-toluenesulfonyl chloride (98-59-9) + (3S)-3-(2-Methoxy-4-methylphenyl)butan-2-ol (217301-15-0) → (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate (1001912-82-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.tetasy.2007.10.019

Reference yield:

(S)-3-(4-Hydroxymethyl-2-methoxy-phenyl)-butan-1-ol (217301-10-5) → (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate (1001912-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / H₂ / Pd/C / ethyl acetate

2: pyridine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1055/s-1998-1905

Reference yield:

4-((S)-2-Carboxy-1-methyl-ethyl)-3-methoxy-benzoic acid ethyl ester (217301-06-9) → (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate (1001912-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / LiAlH₄ / tetrahydrofuran

2: 93 percent / H₂ / Pd/C / ethyl acetate

3: pyridine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1055/s-1998-1905

upstream raw materials:

p-toluenesulfonyl chloride

(3S)-3-(2-Methoxy-4-methylphenyl)butan-2-ol

2-methoxy-4-methylacetophenone

Ethyl (2E)-3-(2-methoxy-4-methylphenyl)but-2-enoate

Downstream raw materials:

(S)-(+)-Curcuphenol methyl ether

(S)-curcumene

(S)-curcuphenol

(3S)-3-(2-Methoxy-4-methylphenyl)butyl iodide