benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Base Information

Chemical Name:benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS No.:1621581-82-5
Molecular Formula:C₂₉H₄₁N₅O₅Si
Molecular Weight:567.761
Hs Code.:

Synonyms:benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Chemical Property of benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Technology Process of benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

There total 14 articles about benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1621508-20-0
2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propan-1-amine

: 1621581-59-6
2-(5-((benzyloxy)carbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)acetic acid

: 1621581-82-5
benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 1621508-17-5
2-bromo-1-(pyrimidin-2-yl)propan-1-one

: 1621581-82-5
benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium formate / deuteromethanol / 8 h / 70 °C

2.1: 1H-imidazole; dmap / dichloromethane / 0.17 h / 0 °C

2.2: 6 h / 0 - 20 °C

3.1: sodium acetate; ammonium carbonate; acetic acid / methanol / 2 h / 70 °C

3.2: 6 h / 70 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium formate; sodium acetate; ammonium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; deuteromethanol;

Reference yield:

: 1621508-18-6
2-hydroxy-1-(pyrimidin-2-yl)propan-1-one

: 1621581-82-5
benzyl 2-(2-((2-((tert-butyldimethylsilyl)oxy)-1-(pyrimidin-2-yl)propyl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole; dmap / dichloromethane / 0.17 h / 0 °C

1.2: 6 h / 0 - 20 °C

2.1: sodium acetate; ammonium carbonate; acetic acid / methanol / 2 h / 70 °C

2.2: 6 h / 70 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium acetate; ammonium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;