(3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

Base Information

Chemical Name:(3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one
CAS No.:162680-36-6
Molecular Formula:C₂₂H₃₅NO₅Si
Molecular Weight:421.609
Hs Code.:

Synonyms:(3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

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Chemical Property of (3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

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Technology Process of (3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

There total 5 articles about (3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 113494-85-2
(3R,4S)-3-<3'-(benzyloxymethoxy)-1'-oxopropyl>-1-(tert-butyldimethylsilyl)-4-(tert-butyldimethylsilyloxymethyl)-3-methylazetidin-2-one

: 162680-36-6
(3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

Guidance literature:: With potassium fluoride; In methanol; at 0 ℃; for 1h;
DOI:10.1039/c39870000992

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 162680-36-6
(3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt, DMAP / CH₂Cl₂

3: 1.) lithium diethylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 4 h

4: PDC, 2A molecular sieves / CH₂Cl₂

5: KF / methanol / 0 °C

With dmap; potassium fluoride; dipyridinium dichromate; molecular sieve; lithium diethylamide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

: (3R,4S)-3-(3-Benzyloxymethoxy-1-hydroxy-propyl)-1-(tert-butyl-dimethyl-silanyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

: 162680-36-6
(3R,4S)-3-(3-Benzyloxymethoxy-propionyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: PDC, 2A molecular sieves / CH₂Cl₂

2: KF / methanol / 0 °C

With potassium fluoride; dipyridinium dichromate; molecular sieve; In methanol; dichloromethane;