(S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

Base Information

Chemical Name:(S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide
CAS No.:1446020-92-3
Molecular Formula:C₂₀H₂₅F₂N₅O
Molecular Weight:389.448
Hs Code.:

Synonyms:(S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

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Chemical Property of (S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

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Technology Process of (S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

There total 2 articles about (S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446021-29-9
(S)-N-(1-(4-(1-(2-chloropyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

: 139364-36-6
(2,2-difluoro-ethyl)-methyl-amine hydrochloride

: 1446020-92-3
(S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1446021-13-1
C₁₃H₁₈N₂O

: 1446020-92-3
(S)-N-(1-(4-(1-(2-((2,2-difluoroethyl)(methyl)amino)pyrimidin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 80 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 200 °C / Microwave irradiation

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;