CID 11593706

Base Information

• Chemical Name: CID 11593706
• CAS No.: 845273-93-0
• Molecular Formula: (C3H7N)m.(C3H5ClO)n.(CH2O3)x
• Molecular Weight: 211.64336
• European Community (EC) Number: 682-521-9
• ChEMBL ID: CHEMBL1201799
• NCI Thesaurus Code: C78122
• RXCUI: 660890
• Mol file: 845273-93-0.mol

Synonyms:Carbonate, Sevelamer;GT335 012;GT335-012;GT335012;Hydrochloride, Sevelamer;RenaGel;sevelamer;sevelamer carbonate;sevelamer hydrochloride

Chemical Property of CID 11593706

Chemical Property:

• PSA: 96.08000
• LogP: 1.67780
• Storage Temp.: Room Temperature, under inert atmosphere
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 211.0611356
• Heavy Atom Count: 13
• Complexity: 81.4

Purity/Quality:

99% ^*data from raw suppliers

Sevelamer carbonate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CCN.C1C(O1)CCl.C(=O)(O)O
• Recent ClinicalTrials: A Study to Evaluate Safety and Efficacy of AP-306 in Hyperphosphatemia Patients
• Recent EU Clinical Trials: Prevention of Aortic Stenosis Pilot Trial
• Description: Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.
• Uses: Sevelamer Carbonate, a non-?absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-?based phosphate binders. Control of serum phosphorus in patients with chronic kidney disease (phosphate binder).

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