(4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

Base Information

Chemical Name:(4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid
CAS No.:1375702-13-8
Molecular Formula:C₂₄H₂₄N₆O₃
Molecular Weight:444.493
Hs Code.:

Synonyms:(4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

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Chemical Property of (4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

There total 4 articles about (4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂HF₃O₂*C₂₇H₂₉N₅O₃

: 1375702-13-8
(4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

Guidance literature:: C₂HF₃O₂*C₂₇H₂₉N₅O₃; With water; sodium hydroxide; In ethanol; at 50 ℃; for 2h;

With hydrogenchloride; In ethanol; pH=2;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1375702-13-8
(4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / palladium diacetate; XPhos / ISOPROPYLAMIDE / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 16 h / 760.05 Torr

3.1: sodium hydrogencarbonate / ISOPROPYLAMIDE / 1.5 h / 150 °C / Inert atmosphere; microwave Irradiation

4.1: sodium hydroxide; water / ethanol / 2 h / 50 °C

4.2: pH 2

With water; hydrogen; sodium hydrogencarbonate; caesium carbonate; sodium hydroxide; palladium hydroxide, 20 wt% on carbon; palladium diacetate; XPhos; In ethanol; ISOPROPYLAMIDE;

Reference yield:

: 1375702-42-3
ethyl [4-(4-benzylpiperazin-1-yl)phenyl]acetate

: 1375702-13-8
(4-{4-[5-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]piperazin-1-yl}phenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 16 h / 760.05 Torr

2.1: sodium hydrogencarbonate / ISOPROPYLAMIDE / 1.5 h / 150 °C / Inert atmosphere; microwave Irradiation

3.1: sodium hydroxide; water / ethanol / 2 h / 50 °C

3.2: pH 2

With water; hydrogen; sodium hydrogencarbonate; sodium hydroxide; palladium hydroxide, 20 wt% on carbon; In ethanol; ISOPROPYLAMIDE;