3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Base Information

Chemical Name:3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid
CAS No.:1332706-63-4
Molecular Formula:C₂₆H₂₃ClN₂O₃
Molecular Weight:446.933
Hs Code.:

Synonyms:3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

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Chemical Property of 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

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Technology Process of 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

There total 11 articles about 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

: 1332706-63-4
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Guidance literature:: benzyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 80 ℃; for 16h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 1332706-63-4
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid; N-iodo-succinimide / 50 °C

2: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

3: potassium hydroxide / ethanol / 3 h / Reflux

4: potassium carbonate / acetone / 0 - 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

6: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 80 °C

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 80 °C

With potassium phosphate; N-iodo-succinimide; tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 16205-98-4
3-oxo-cyclohexanecarboxylic acid

: 1332706-63-4
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 1 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 0.33 h / 0 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 80 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 80 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;