(3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate

Base Information

• Chemical Name: (3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate
• CAS No.: 115534-13-9
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.348
• Mol file: 115534-13-9.mol

Synonyms:(3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate

Chemical Property of (3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate

There total 1 articles about (3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4,4-dimethylpent-1-yn-3-ol (61317-72-4) + (R)-(+)-α-methylbenzyl formamide (6948-01-2,19145-06-3,31502-34-8,42412-77-1) → (3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate (115534-13-9) + (3S,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate (115534-14-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; at 80 ℃; for 5h;

DOI:10.1021/jo00255a014

Reference yield:

(3R,1'R)-4,4-dimethylpent-1-yn-3-ol, (1'-phenylethyl)-carbamate (115534-13-9) → Phenyl-carbamic acid 2,6,6-trimethyl-hepta-3,4-dienyl ester (115534-19-5,115534-20-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 2.5 h / Heating

2: 92 percent / C₂H₅COOH / 5.5 h / 80 °C

3: 99 percent / LiAlH₄ / diethyl ether / 1 h

4: 86 percent / 1). RT, 1 h, 2). 60 deg C, 2 h,

With lithium aluminium tetrahydride; propionic acid; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00255a014

upstream raw materials:

4,4-dimethylpent-1-yn-3-ol

(R)-(+)-α-methylbenzyl formamide

Downstream raw materials:

Phenyl-carbamic acid 2,6,6-trimethyl-hepta-3,4-dienyl ester