N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine

Base Information

Chemical Name:N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine
CAS No.:267243-74-3
Molecular Formula:C₁₅H₁₂ClFN₄O₂S
Molecular Weight:366.803
Hs Code.:
DSSTox Substance ID:DTXSID401126372

Synonyms:DTXSID401126372;N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine;267243-74-3

Suppliers and Price of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:366.0353527
Heavy Atom Count:24
Complexity:463

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(N=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)S(=O)C

Technology Process of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine

There total 8 articles about N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(methylsulfinyl)pyrido[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 267243-70-9
4-[N-(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-(methylthio)pyrido[3,2-9]pyrimidine

: 267243-74-3
4-[N-(3-chloro-4-fluorophenyl)amino]-6-(methanesulfinyl)-7-methoxypyrido[3,2-9]pyrimidine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm990482t

Reference yield:

: 127356-33-6
2-bromo-5-methoxy-6-(methylthio)-3-nitropyridine

: 267243-74-3
4-[N-(3-chloro-4-fluorophenyl)amino]-6-(methanesulfinyl)-7-methoxypyrido[3,2-9]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / 1-methyl-pyrrolidin-2-one / 0.17 h / 170 °C

2: Fe; aq. HOAc / ethanol / 0.5 h / Heating

3: H₂SO₄ / 16 h / Heating

4: POCl₃ / 1.83 h / Heating

5: aq. HCl / propan-2-ol / 0.5 h / 60 °C

6: 97 percent / m-CPBA / CH₂Cl₂ / 1 h / 20 °C

With hydrogenchloride; sulfuric acid; iron; acetic acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; isopropyl alcohol; 1: Substitution / 2: Reduction / 3: cyclocondensation / 4: Chlorination / 5: Condensation / 6: Oxidation;
DOI:10.1021/jm990482t

Reference yield:

: 267243-56-1
2-cyano-5-methoxy-6-(methylthio)-3-nitropyridine

: 267243-74-3
4-[N-(3-chloro-4-fluorophenyl)amino]-6-(methanesulfinyl)-7-methoxypyrido[3,2-9]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: Fe; aq. HOAc / ethanol / 0.5 h / Heating

2: H₂SO₄ / 16 h / Heating

3: POCl₃ / 1.83 h / Heating

4: aq. HCl / propan-2-ol / 0.5 h / 60 °C

5: 97 percent / m-CPBA / CH₂Cl₂ / 1 h / 20 °C

With hydrogenchloride; sulfuric acid; iron; acetic acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In ethanol; dichloromethane; isopropyl alcohol; 1: Reduction / 2: cyclocondensation / 3: Chlorination / 4: Condensation / 5: Oxidation;
DOI:10.1021/jm990482t