benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

Base Information

Chemical Name:benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate
CAS No.:104834-51-7
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:378.429
Hs Code.:

Synonyms:benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

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Chemical Property of benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

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Technology Process of benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

There total 5 articles about benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.4%

: 3228-27-1,89277-65-6
[13C]-formaldehyde

: 62562-74-7
benzyl 4-<<(benzyloxy)carbonyl>methyl>-2-methylpyrrole-5-carboxylate

: 104834-51-7
benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

Guidance literature:: With Celite; hydrogen iodide; hypophosphorous acid; In acetic acid; at 25 ℃; for 30.5h;
DOI:10.1021/jo00374a031

Reference yield:

: 50622-73-6
methyl 3-<(methoxycarbonyl)methyl>-5-methylpyrrole-2-carboxylate

: 104834-51-7
benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / sodium / 120 °C / 45 Torr

2: 15.4 percent / hydriodic acid, hypophorphorus acid, celite / acetic acid / 30.5 h / 25 °C

With Celite; hydrogen iodide; hypophosphorous acid; sodium; In acetic acid;
DOI:10.1021/jo00374a031

Reference yield:

: 868-09-7
2-hydroxyimino-3-oxo-pentanedioic acid dimethyl ester

: 104834-51-7
benzyl 3-<<(benzyloxy)carbonyl>methyl>-4,5-<4-13C>dimethylpyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: glacial acetic acid, zinc, ammonium acetate / 4 h / 60 °C

2: 95 percent / trifluoroacetic acid / 1 h / 50 °C

3: 26.5 percent / copper(II) acetate, quinoline / 1.) 160 deg C, 30 min, 2.) 210 deg C, 3 h

4: 81 percent / sodium / 120 °C / 45 Torr

5: 15.4 percent / hydriodic acid, hypophorphorus acid, celite / acetic acid / 30.5 h / 25 °C

With quinoline; ammonium acetate; Celite; hydrogen iodide; copper diacetate; hypophosphorous acid; sodium; acetic acid; trifluoroacetic acid; zinc; In acetic acid;
DOI:10.1021/jo00374a031