8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Base Information

• Chemical Name: 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
• CAS No.: 928788-76-5
• Molecular Formula: C₃₂H₃₆N₆O₃
• Molecular Weight: 552.676

Synonyms:8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Chemical Property of 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

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Technology Process of 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

There total 1 articles about 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

4-[2-(4-methylpiperazin-1-yl)-ethyl]-phenylamine (262368-48-9) + 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (928639-97-8) → 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (928788-76-5)

Guidance literature:

In isopropyl alcohol; at 90 ℃; for 1h;

DOI:10.1021/jm801406h

Reference yield: 60.0%

8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (928788-76-5) + O-ethylhydroxylamine hydrochloride (3332-29-4) → 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethoxyamide (1023273-87-1)

Guidance literature:

With triethylamine; In methanol; at 100 ℃;

DOI:10.1021/jm801406h

Reference yield: 46.0%

8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (928788-76-5) + isopropoxyamine hydrochloride (4490-81-7) → 8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid isopropoxyamide (1023273-88-2)

Guidance literature:

With triethylamine; In methanol; at 100 ℃;

DOI:10.1021/jm801406h

upstream raw materials:

4-[2-(4-methylpiperazin-1-yl)-ethyl]-phenylamine

8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Downstream raw materials:

8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid methoxyamide

8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethoxyamide

8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid isopropoxyamide

8-indan-5-yl-2-{4-[2-(4-methylpiperazin-1-yl)-ethyl]phenylamino}-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid (2-hydroxyethyl)amide

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