(S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

Base Information

Chemical Name:(S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide
CAS No.:748143-81-9
Molecular Formula:C₁₇H₂₆ClN₃O₃
Molecular Weight:355.865
Hs Code.:

Synonyms:(S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

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Chemical Property of (S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

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Technology Process of (S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

There total 6 articles about (S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 322392-25-6
tert-butyl (S)-(1-(4-chlorophenyl)-3-oxopropan-2-yl)carbamate

: 13734-41-3,22838-58-0,54895-12-4
N-Boc-(S/R)-valine

: 109-90-0
ethyl isocyanate

: 748143-81-9
(S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

Guidance literature:: tert-butyl (S)-(1-(4-chlorophenyl)-3-oxopropan-2-yl)carbamate; N-Boc-(S/R)-valine; ethyl isocyanate; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: (S)-2-Amino-3-methyl-butyric acid (S)-2-amino-3-(4-chloro-phenyl)-1-ethylcarbamoyl-propyl ester

: 748143-81-9
(S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2005.08.064

Reference yield:

: 322392-25-6
tert-butyl (S)-(1-(4-chlorophenyl)-3-oxopropan-2-yl)carbamate

: 748143-81-9
(S)-2-Amino-N-[(S)-1-(4-chloro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 20 °C

2: TFA / CH₂Cl₂ / 0 - 20 °C

3: Et₃N / CH₂Cl₂ / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; 1: Passerini reaction;
DOI:10.1016/j.bmcl.2005.08.064