sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

Base Information

• Chemical Name: sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide
• CAS No.: 1604777-60-7
• Molecular Formula: C₂₃H₂₀F₆N₂O₃P*Na
• Molecular Weight: 540.377

Synonyms:sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

Chemical Property of sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

Chemical Property:

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Technology Process of sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

There total 4 articles about sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-49-2) → sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decan-2-olate 2-oxide (1604777-60-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; for 15h; Reflux;

DOI:10.2174/15734064113099900002

Reference yield:

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.13,7]decan-6-one (1053242-58-2) → sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decan-2-olate 2-oxide (1604777-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / acetonitrile / 20 °C / Reflux

2: sodium hydroxide / tetrahydrofuran; water / 15 h / Reflux

With pyridine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; acetonitrile;

DOI:10.2174/15734064113099900002

Reference yield:

4-(trifluoromethyl)benzylic alcohol (349-95-1) → sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decan-2-olate 2-oxide (1604777-60-7)

Guidance literature:

Multi-step reaction with 4 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenylphosphine; potassium hydroxide / 100 °C

2: acetic acid / ethanol / 15 h / Reflux

3: pyridine; trichlorophosphate / acetonitrile / 20 °C / Reflux

4: sodium hydroxide / tetrahydrofuran; water / 15 h / Reflux

With pyridine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; acetic acid; triphenylphosphine; potassium hydroxide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; acetonitrile; 2: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

upstream raw materials:

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

4-(trifluoromethyl)benzylic alcohol

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone

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