10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester

Base Information

• Chemical Name: 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester
• CAS No.: 182008-80-6
• Molecular Formula: C₂₇H₃₄O₄Si
• Molecular Weight: 450.65
• Mol file: 182008-80-6.mol

Synonyms:10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester

Chemical Property of 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester

There total 6 articles about 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-[1,3]dithian-2-yl}-pent-2-ynoic acid methyl ester → 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester (182008-80-6)

Guidance literature:

With N-chloro-succinimide; silver nitrate; In water; acetonitrile; Yield given;

DOI:10.1016/0040-4039(96)01206-3

Reference yield:

3-(2-(4-((tert-butyldiphenylsilyl)oxy)butyl)-1,3-dithian-2-yl)propan-1-ol (182008-78-2) → 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester (182008-80-6)

Guidance literature:

Multi-step reaction with 5 steps

1: DMSO, Et₃N, SO₃*Py / CH₂Cl₂ / 0.33 h / Ambient temperature

2: Ph₃P / CH₂Cl₂ / 1 h / 0 °C

3: 94 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 60 min, 2.) -78 deg C, 60 min and warm to room temperature.

5: NCS, AgNO₃ / H₂O; acetonitrile / 0.25 h / -5 °C

With N-chloro-succinimide; n-butyllithium; pyridine-SO₃ complex; silver nitrate; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(98)00241-5

Reference yield:

3-(2-(4-((tert-butyldiphenylsilyl)oxy)butyl)-1,3-dithian-2-yl)propanal (182008-96-4) → 10-(tert-Butyl-diphenyl-silanyloxy)-6-oxo-dec-2-ynoic acid methyl ester (182008-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Ph₃P / CH₂Cl₂ / 1 h / 0 °C

2: 94 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 60 min, 2.) -78 deg C, 60 min and warm to room temperature.

4: NCS, AgNO₃ / H₂O; acetonitrile / 0.25 h / -5 °C

With N-chloro-succinimide; n-butyllithium; silver nitrate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(98)00241-5

upstream raw materials:

3-(2-(4-((tert-butyldiphenylsilyl)oxy)butyl)-1,3-dithian-2-yl)propan-1-ol

3-(2-(4-((tert-butyldiphenylsilyl)oxy)butyl)-1,3-dithian-2-yl)propanal

tert-Butyl-{4-[2-(4,4-dibromo-but-3-enyl)-[1,3]dithian-2-yl]-butoxy}-diphenyl-silane

tert-butyldiphenyl(4-(2-(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-1,3-dithian-2-yl)butoxy)silane