methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Base Information

Chemical Name:methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate
CAS No.:1426133-30-3
Molecular Formula:C₂₇H₃₀N₆O₅
Molecular Weight:518.572
Hs Code.:

Synonyms:methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

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Chemical Property of methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

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Technology Process of methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

There total 12 articles about methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426133-28-9
methyl 3-(3-(4-methyl-3-(6-(3-oxobutyl)imidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

: 1426133-30-3
methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 1426136-20-0
ethyl 6-(3-oxo-but-1-enyl)imidazo[1,2-a]pyridine-3-carboxylate

: 1426133-30-3
methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate; ethanol

2.1: lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 50 °C

2.2: 20 °C / pH 3 - 5

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: pyridine / 0.33 h / 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 0.25 h / -78 - 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 1426136-21-1
ethyl 6-(3-oxobutyl)imidazo[1,2-a]pyridine-3-carboxylate

: 1426133-30-3
methyl 3-(3-(3-(6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 50 °C

1.2: 20 °C / pH 3 - 5

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: pyridine / 0.33 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 0.25 h / -78 - 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;