(R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine

Base Information

• Chemical Name: (R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine
• CAS No.: 208539-59-7
• Molecular Formula: C₁₉H₁₇N
• Molecular Weight: 259.351
• Mol file: 208539-59-7.mol

Synonyms:(R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine

Chemical Property of (R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine

There total 1 articles about (R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 1-naphthaldehyde (66-77-3) → (R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine (208539-59-7)

Guidance literature:

In toluene; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja207550t

Reference yield: 85.0%

(R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine (208539-59-7) → (R)-N-(naphthalen-1-ylmethyl)-1-phenylethanamine hydrochloride (1349194-47-3)

Guidance literature:

(R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; for 0.5h; Inert atmosphere;

DOI:10.1021/ja207550t

Reference yield:

(R)-N-(naphthalen-1-ylmethylene)-1-phenylethanamine (208539-59-7) + Acetoxyacetyl chloride (13831-31-7) → C23H21NO3

Guidance literature:

With triethylamine; In dichloromethane; at -10 - 20 ℃; for 24h;

DOI:10.1002/chir.20470

upstream raw materials:

(R)-1-phenyl-ethyl-amine

1-naphthaldehyde

Downstream raw materials:

(R)-N-(naphthalen-1-ylmethyl)-1-phenylethanamine hydrochloride

(1'R,2R,3R)-1-(1'-phenylethyl)-2-(1'-naphthyl)-3-hydroxyazetidine

(1'R,2S,3S)-1-(1'-phenylethyl)-2-(1'-naphthyl)-3-hydroxyazetidine

Refernces

• 1、 Zhang, Zhanbin,Li, Min,Zi, Guofu. "Synthesis of new chiral cis-3-hydroxyazetidines and their application in diethylzinc addition to aldehydes". . p. 802 - 808. Retrieved 2013/08/22.