2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

Base Information

Chemical Name:2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid
CAS No.:1235032-77-5
Molecular Formula:C₃₀H₂₆N₄O₄S₂
Molecular Weight:570.693
Hs Code.:

Synonyms:2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

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Chemical Property of 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

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Technology Process of 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

There total 11 articles about 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878798-87-9
2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid

: 1235032-77-5
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

2.1: hydrogenchloride / water; dichloromethane; diethyl ether / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h / 20 °C

4.1: ammonia / methanol

5.1: ethanol / 6 h / 50 °C / Inert atmosphere

6.1: sodium iodide / acetonitrile / 5 h / 90 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

7.2: 1 h

8.1: hydrogenchloride / water

With hydrogenchloride; dmap; ammonia; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium iodide; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml500030p

Reference yield:

: C₃₂H₃₀N₄O₄S₂

: 1235032-77-5
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

Guidance literature:: C₃₂H₃₀N₄O₄S₂; With water; sodium hydroxide; In N,N-dimethyl-formamide; at 50 ℃; for 5h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1235035-45-6
N-(benzo[d]thiazol-2-yl)-2-carbamothioyl-1,2,3,4-tetrahydroisoquinoline-8-carboxamide

: 1235032-77-5
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-phenoxypropyl)thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 6 h / 50 °C / Inert atmosphere

2.1: sodium iodide / acetonitrile / 5 h / 90 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 1 h

4.1: hydrogenchloride / water

With hydrogenchloride; sodium hydride; sodium iodide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml500030p