[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

Base Information

Chemical Name:[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester
CAS No.:1590398-13-2
Molecular Formula:C₁₇H₁₈F₃N₃O₂
Molecular Weight:353.344
Hs Code.:

Synonyms:[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

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Chemical Property of [3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

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Technology Process of [3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

There total 1 articles about [3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 799557-86-1
5-bromo-2-(trifluoromethyl)-pyrimidine

: 199609-62-6
(3-{[(tert-butoxycarbonyl)amino]methyl}phenyl)boronic acid

: 1590398-13-2
[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 14h; Inert atmosphere; Sealed tube;

Reference yield: 89.0%

: 1590398-13-2
[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

: 1590398-14-3
[3-[2-(trifluoromethyl)pyrimidin-5-yl]phenyl]methylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 3h;

Reference yield:

: 1590398-13-2
[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]carbamic acid tert-butylester

: 1590397-49-1
2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[3-(2-trifluoromethylpyrimidin-5-yl)benzyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 25 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;