(5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

Base Information

Chemical Name:(5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine
CAS No.:1372710-57-0
Molecular Formula:C₃₅H₄₂N₂O₉SSi
Molecular Weight:694.878
Hs Code.:

Synonyms:(5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

Suppliers and Price of (5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

Chemical Property:

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Technology Process of (5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

There total 6 articles about (5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1372710-55-8
(5'S)-3'-O-(tert-butyldiphenylsilyl)-5'-C-(2-hydroxyethyl)-2'-O-methyluridine

: 98-59-9
p-toluenesulfonyl chloride

: 1372710-57-0
(5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

Guidance literature:: With pyridine; In chloroform; at 0 ℃; for 12h; chemoselective reaction;
DOI:10.1002/ejoc.201101353

Reference yield:

: 1384867-01-9
C₂₈H₃₆N₂O₇Si

: 98-59-9
p-toluenesulfonyl chloride

: 1372710-66-1
(5'R)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

: 1372710-57-0
(5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

Guidance literature:: With pyridine; In chloroform; at 0 ℃; for 12h;
DOI:10.1002/ejoc.201101353

Reference yield:

: 1372710-52-5
(5'S)-3'-O-(tert-butyldiphenylsilyl)-5'-C-(methoxycarbonylmethyl)-2'-O-methyluridine

: 1372710-57-0
(5'S)-3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-C-(2-tosyloxyethyl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C

2: pyridine / chloroform / 12 h / 0 °C

With pyridine; sodium tetrahydroborate; In ethanol; chloroform;
DOI:10.1002/ejoc.201101353