C₁₇H₂₇N₃O₂Si

Base Information

• Chemical Name: C₁₇H₂₇N₃O₂Si
• CAS No.: 1026612-28-1
• Molecular Formula: C₁₇H₂₇N₃O₂Si
• Molecular Weight: 333.506
• Mol file: 1026612-28-1.mol

Synonyms:C₁₇H₂₇N₃O₂Si

Chemical Property of C₁₇H₂₇N₃O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₂₇N₃O₂Si

There total 7 articles about C₁₇H₂₇N₃O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-3-phenyl-2-propen-1-ol (4407-36-7) → C17H27N3O2Si (1026612-28-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 89 percent / (2S,3S)-(-)-diisopropyl tartrate; activated molecular sieves 4 Angstroem; TBHP / Ti(Oi-Pr)4 / CH₂Cl₂ / 3.5 h / -20 °C

2: 98 percent / NaN₃; NH₄Cl; H₂O / methanol / 5 h / 65 °C

3: pyridine / CH₂Cl₂ / 0 - 20 °C

4: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 20 °C

5: 5.08 g / K₂CO₃ / methanol / 20 °C

6: 65 percent / TiCl₄ / CH₂Cl₂ / 1.5 h / -78 °C

7: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

8: 2,6-lutidine; OsO₄; NaIO₄ / dioxane; H₂O; toluene / 3 h / 25 °C

With pyridine; 2,6-dimethylpyridine; tert.-butylhydroperoxide; dmap; sodium periodate; osmium(VIII) oxide; sodium azide; 4 A molecular sieve; water; titanium tetrachloride; potassium carbonate; ammonium chloride; triethylamine; titanium(IV) isopropylate; In 1,4-dioxane; methanol; dichloromethane; water; toluene; 1: Sharpless asymmetric epoxidation;

DOI:10.1016/j.tetasy.2007.04.006

Reference yield:

({(1S)-1-[(S)-azido(phenyl)methyl]-pent-4-enyl}oxy)(tert-butyl)dimethylsilane (944324-85-0) → C17H27N3O2Si (1026612-28-1)

Guidance literature:

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; toluene; at 25 ℃; for 3h;

DOI:10.1016/j.tetasy.2007.04.006

Reference yield:

(2S,3S)-3-azido-2-hydroxy-3-phenylpropyl pivalate → C17H27N3O2Si (1026612-28-1)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 5.08 g / K₂CO₃ / methanol / 20 °C

3: 65 percent / TiCl₄ / CH₂Cl₂ / 1.5 h / -78 °C

4: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5: 2,6-lutidine; OsO₄; NaIO₄ / dioxane; H₂O; toluene / 3 h / 25 °C

With 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; toluene;

DOI:10.1016/j.tetasy.2007.04.006

upstream raw materials:

({(1S)-1-[(S)-azido(phenyl)methyl]-pent-4-enyl}oxy)(tert-butyl)dimethylsilane

(1S,2S)-1-azido-1-phenyl-hex-5-en-2-ol

(2S,3S)-3-azido-2-((methylsulfonyl)oxy)-3-phenylpropyl pivalate

(2R)-2-[(S)-azido(phenyl)methyl]oxirane

Downstream raw materials:

C₁₇H₂₇NOSi

(2S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-piperidine

L 733060

tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate