10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

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Chemical Name:10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide
CAS No.:1442371-99-4
Molecular Formula:C₄₅H₅₁N₇O₄SSi
Molecular Weight:814.096
Hs Code.:

Synonyms:10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

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Chemical Property of 10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

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Technology Process of 10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

There total 5 articles about 10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 109-01-3
1-methyl-piperazine

: 1442371-96-1
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-chloro-10H-phenothiazine 5,5-dioxide

: 1442371-99-4
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; XPhos; In toluene; at 70 - 90 ℃; for 1.16667h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 1387627-09-9
1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol

: 1442371-99-4
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dichloromethane / 96 h / 0 - 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

4: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 1.17 h / 70 - 90 °C / Inert atmosphere

With 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; XPhos; In dichloromethane; toluene; 4: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1442371-99-4
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-(4-methylpiperazin-1-yl)-10H-phenothiazine 5,5-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dichloromethane / 96 h / 0 - 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

4: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 1.17 h / 70 - 90 °C / Inert atmosphere

With 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; XPhos; In dichloromethane; toluene; 4: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034